231 Triple-Negative Breast Cancers (TNBCs) Rich in Plasma Cells Have Improved Prognosis
نویسندگان
چکیده
منابع مشابه
Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)
Triple Negative Breast Cancer (TNBC) is defined by the lack of ERα, PR expression and HER2 overexpression and is the breast cancer subtype with the poorest clinical outcomes. Our aim was to identify genes driving TNBC proliferation and/or survival which could represent novel therapeutic targets.We performed microarray profiling of primary TNBCs and generated differential genelists based on clin...
متن کاملPatients with Concordant Triple-Negative Phenotype between Primary Breast Cancers and Corresponding Metastases Have Poor Prognosis
PURPOSE We investigated the prognostic impact of discordance between the receptor status of primary breast cancers and corresponding metastases. METHODS A total 144 patients with breast cancer and distant metastasis were investigated. The estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status of primary tumor and corresponding metastases...
متن کاملThe omics of triple-negative breast cancers.
BACKGROUND Triple-negative breast cancers (TNBC) do not represent a single disease subgroup and are often aggressive breast cancers with poor prognoses. Unlike estrogen/progesterone receptor and HER2 (human epidermal growth factor receptor 2) breast cancers, which are responsive to targeted treatments, there is no effective targeted therapy for TNBC, although approximately 50% of patients respo...
متن کاملTreatment Options for Triple-negative Breast Cancers
grade (severity). Identification of molecular markers such as expression of the estrogen (er) and progesterone receptors (pgr) and the human epidermal growth factor receptor 2 (her2) has offered additional predictive value for the therapeutic assessment of women diagnosed with breast cancer 1–4. More recently, gene expression analysis using dna microarray technology has identified additional br...
متن کاملMolecular stratification of triple-negative breast cancers.
Research focused on the analysis and classification of breast tumors, primarily using DNA microarrays and patterns of gene expression, has resulted in distinct tumor subtypes. Although no knowledge of patient survival or outcomes was used to derive these gene descriptions, these different classes based upon patterns of gene expression have important prognostic implications. Predictive markers i...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2018
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/aqx123.230